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Roy2019 - A vivid cytokines interaction model on psoriasis with the effect of impulse biologic therapy

ABSTRACT: This is a mathematical model describing keratinocyte proliferation dynamics as influenced by immune cells and cytokines within the context of psoriasis. The model also investigates the perfect dosing interval for therapeutic dosages of TNF-alpha inhibitors for the treatment of psoriasis.

SUBMITTER: Johannes Meyer

PROVIDER: MODEL1911070001 | BioModels | 2019-11-07

REPOSITORIES: BioModels

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A vivid cytokines interaction model on psoriasis with the effect of impulse biologic (TNF-α inhibitor) therapy.

Roy Amit Kumar AK Al Basir Fahad F Roy Priti Kumar PK

Journal of theoretical biology 20190411

Psoriasis is a chronic skin condition that produces plaques of condensed, scaling skin due to excessively rapid proliferation of keratinocytes. During the disease progression, keratinocyte proliferation is influenced by many immune cells and cytokines. This article deals with a five dimensional deterministic model, which has been derived using quasi-steady-state approximation for describing the dynamics of psoriasis in various cytokines environment. Equilibrium analysis of the system shows that ...[more]

PMID: 30980871

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