Dataset Information
Gupta2019 - Restoration of cytosolic calcium inhibits Mycobacterium tuberculosis intracellular growth
Ontology highlight
ABSTRACT:
SUBMITTER: 
Johannes Meyer
PROVIDER: MODEL1911120004 | BioModels | 2019-11-13
REPOSITORIES: BioModels
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| MODEL1911120004?filename=Gupta2019.cps | Other | |||
| MODEL1911120004?filename=Gupta2019.xml | Xml |
Items per page: 1 - 2 of 2 |
Publications
Restoration of cytosolic calcium inhibits Mycobacterium tuberculosis intracellular growth: Theoretical evidence and experimental observation.
Journal of theoretical biology 20190416
Mycobacterium tuberculosis (Mtb) is a highly successful intracellular pathogen because of its ability to modulate host's anti-microbial pathways. Phagocytosis acts as the first line of defence against microbial infection. However, Mtb inhibits Phosphatidylinositol 3-phosphate (PI3P) oscillations which is required for phagolysosomal fusion. Here we attempted to understand the mechanisms by which Mtb eliminates phagosome-lysosome fusion. To address this, we built a four dimensional ordinary differ ...[more]
