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Boer1985 - Macrophage T cell interaction in anti-tumor response

ABSTRACT: In this paper we present a model of the macrophage T lymphocyte interactions that generate an anti-tumor immune response. The modseple cifies i) induction of cytotoxic T lymphocytes, ii) antigen presentation by macrophages, which leads to iii) activation of helper T cells, and iv) production of lymphoid factors, which induce a) cytotoxic macrophages, b) T lymphocyte proliferation, and c) an inflammation reaction. Tumor escape mechanisms (suppression, antigenic heterogeneity) have been deliberately omitted from the model.

SUBMITTER: Krishna Kumar Tiwari

PROVIDER: MODEL1911130003 | BioModels | 2019-11-13

REPOSITORIES: BioModels

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Macrophage T lymphocyte interactions in the anti-tumor immune response: a mathematical model.

De Boer R J RJ Hogeweg P P Dullens H F HF De Weger R A RA Den Otter W W

Journal of immunology (Baltimore, Md. : 1950) 19850401 4

In this paper we present a model of the macrophage T lymphocyte interactions that generate an anti-tumor immune response. The model specifies i) induction of cytotoxic T lymphocytes, ii) antigen presentation by macrophages, which leads to iii) activation of helper T cells, and iv) production of lymphoid factors, which induce a) cytotoxic macrophages, b) T lymphocyte proliferation, and c) an inflammation reaction. Tumor escape mechanisms (suppression, antigenic heterogeneity) have been deliberate ...[more]

PMID: 3156189

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