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Boer1985 - Macrophage T cell interaction in anti-tumor response

ABSTRACT: In this paper we present a model of the macrophage T lymphocyte interactions that generate an anti-tumor immune response. The modseple cifies i) induction of cytotoxic T lymphocytes, ii) antigen presentation by macrophages, which leads to iii) activation of helper T cells, and iv) production of lymphoid factors, which induce a) cytotoxic macrophages, b) T lymphocyte proliferation, and c) an inflammation reaction. Tumor escape mechanisms (suppression, antigenic heterogeneity) have been deliberately omitted from the model.

SUBMITTER: Krishna Kumar Tiwari