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Tiwari2019 - Mathematical model of NFKB regulatory module with TNF and ROS


ABSTRACT: It is a dynamic model containing elements of two different model as one. It contains the impact of TNF on SOD and impact of ROS on A20 behavior.

SUBMITTER: Krishna Kumar Tiwari  

PROVIDER: MODEL1911140002 | BioModels | 2022-03-31

REPOSITORIES: BioModels

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Mathematical model of NF-kappaB regulatory module.

Lipniacki Tomasz T   Paszek Pawel P   Brasier A R Allan R AR   Luxon Bruce B   Kimmel Marek M  

Journal of theoretical biology 20040501 2


The two-feedback-loop regulatory module of nuclear factor kappaB (NF-kappaB) signaling pathway is modeled by means of ordinary differential equations. The constructed model involves two-compartment kinetics of the activators IkappaB (IKK) and NF-kappaB, the inhibitors A20 and IkappaBalpha, and their complexes. In resting cells, the unphosphorylated IkappaBalpha binds to NF-kappaB and sequesters it in an inactive form in the cytoplasm. In response to extracellular signals such as tumor necrosis f  ...[more]

Publication: 1/2

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