Ontology highlight
ABSTRACT:
SUBMITTER: Ahmed Mobeen
PROVIDER: MODEL2001290001 | BioModels | 2022-05-27
REPOSITORIES: BioModels
McGillicuddy Fiona C FC Chiquoine Elise H EH Hinkle Christine C CC Kim Roy J RJ Shah Rachana R Roche Helen M HM Smyth Emer M EM Reilly Muredach P MP
The Journal of biological chemistry 20090923 46
Recent reports demonstrate T-cell infiltration of adipose tissue in early obesity. We hypothesized that interferon (IFN) gamma, a major T-cell inflammatory cytokine, would attenuate human adipocyte functions and sought to establish signaling mechanisms. Differentiated human adipocytes were treated with IFNgamma +/- pharmacological inhibitors prior to insulin stimulation. [(3)H]Glucose uptake and AKT phosphorylation were assessed as markers of insulin sensitivity. IFNgamma induced sustained loss ...[more]