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Thomson2009 – Unlimited multistability in multisite phosphorylation systems

ABSTRACT: This model describes a distributive, sequential system with n = 4, which is a simplified example of unlimited multistability in multisite phosphorylation systems. This method can be applied to systems with multiple substrates and enzymes. This model is described in the article: Unlimited multistability in multisite phosphorylation systems. Thomson, Matthew & Gunawardena, Jeremy. (2009). Nature. 460. 274-7. 10.1038/nature08102 ( Antimony and Tellurium used. Figure 2 of the reference publication has been reproduced. The code files are available on Github ( The simulation was performed using Spyder for Tellurium 3.7 (


PROVIDER: MODEL2002110001 | BioModels | 2020-02-12


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Unlimited multistability in multisite phosphorylation systems.

Thomson Matthew M   Gunawardena Jeremy J  

Nature 20090617 7252

Reversible phosphorylation on serine, threonine and tyrosine is the most widely studied posttranslational modification of proteins. The number of phosphorylated sites on a protein (n) shows a significant increase from prokaryotes, with n </= 7 sites, to eukaryotes, with examples having n >/= 150 sites. Multisite phosphorylation has many roles and site conservation indicates that increasing numbers of sites cannot be due merely to promiscuous phosphorylation. A substrate with n sites has an expon  ...[more]

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