Dataset Information

Floc'hlay2020 - SeaUrchin_model_ginsim

ABSTRACT: Multilevel logical model encompassing the Nodal and BMP pathways together with key transcription factors setting the dorsal-ventral axis in the sea urchin P. lividus embryo. This model accounts for the specification of wild-type ventral ectoderm, ciliary band and dorsal ectoderm, and further recapitulates sophisticated mutant phenotypes.

SUBMITTER: Denis Thieffry

PROVIDER: MODEL2002190001 | BioModels | 2021-01-06

REPOSITORIES: BioModels

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Publications

Deciphering and modelling the TGF-β signalling interplays specifying the dorsal-ventral axis of the sea urchin embryo.

Floc'hlay Swann S Molina Maria Dolores MD Hernandez Céline C Haillot Emmanuel E Thomas-Chollier Morgane M Lepage Thierry T Thieffry Denis D

Development (Cambridge, England) 20210120 2

During sea urchin development, secretion of Nodal and BMP2/4 ligands and their antagonists Lefty and Chordin from a ventral organiser region specifies the ventral and dorsal territories. This process relies on a complex interplay between the Nodal and BMP pathways through numerous regulatory circuits. To decipher the interplay between these pathways, we used a combination of treatments with recombinant Nodal and BMP2/4 proteins and a computational modelling approach. We assembled a logical model ...[more]

PMID: 33298464

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Dataset Information

Floc'hlay2020 - SeaUrchin_model_ginsim

Publications

Deciphering and modelling the TGF-β signalling interplays specifying the dorsal-ventral axis of the sea urchin embryo.

Similar Datasets

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