Dataset Information

Rouhimoghadam2018 - GPR30/PI3K/MAPK/STAT signaling pathway in normal and cancer cells

ABSTRACT: In the current study, we aimed to simulate the GPR30/PI3K/MAPK/STAT signaling pathway in normal and cancer cells by the use of ordinary differential equation modeling. In addition, we planned to show that MAPK activation pattern is different between normal and cancer models.

SUBMITTER: Krishna Kumar Tiwari

PROVIDER: MODEL2002250001 | BioModels | 2020-03-16

REPOSITORIES: BioModels

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			Action	DRS
	MODEL2002250001?filename=Rouhimoghadam2018.cps	Other
	MODEL2002250001?filename=Rouhimoghadam2018.sedml	Other
	MODEL2002250001?filename=Rouhimoghadam2018.xml	Xml

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Publications

Tamoxifen-Induced Apoptosis of MCF-7 Cells via GPR30/PI3K/MAPKs Interactions: Verification by ODE Modeling and RNA Sequencing.

Rouhimoghadam Milad M Safarian Shahrokh S Carroll Jason S JS Sheibani Nader N Bidkhori Gholamreza G

Frontiers in physiology 20180711

Tamoxifen (Nolvadex) is one of the most widely used and effective therapeutic agent for breast cancer. It benefits nearly 75% of patients with estrogen receptor (ER)-positive breast cancer that receive this drug. Its effectiveness is mainly attributed to its capacity to function as an ER antagonist, blocking estrogen binding sites on the receptor, and inhibiting the proliferative action of the receptor-hormone complex. Although, tamoxifen can induce apoptosis in breast cancer cells via upregulat ...[more]

PMID: 30050469

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