Models

Dataset Information

0

Loccisano2011-pharmacokinetics of PFOA and PFOS in the monkey


ABSTRACT: Perfluoroalkyl acid carboxylates and sulfonates (PFAAs) have many consumer and industrial applications. The persistence and widespread distribution of these compounds in humans have brought them under intense scrutiny. Limited pharmacokinetic data is available in humans; however, human data exists for two communities with drinking water contaminated by PFAAs. Also, there is toxicological and pharmacokinetic data for monkeys, which can be quite useful for cross-species extrapolation to humans. The goal of this research was to develop a physiologically-based pharmacokinetic (PBPK) model for PFOA and PFOS for monkeys and then scale this model to humans in order to describe available human drinking water data. The monkey model simulations were consistent with available PK data for monkeys. The monkey model was then extrapolated to the human and then used to successfully simulate the data collected from residents of two communities exposed to PFOA in drinking water. Human PFOS data is minimal; however, using the half-life estimated from occupational exposure, our model exhibits reasonable agreement with the available human serum PFOS data. It is envisioned that our PBPK model will be useful in supporting human health risk assessments for PFOA and PFOS by aiding in understanding of human pharmacokinetics. Model is encoded by Ruby and submitted to BioModels by Ahmad Zyoud

SUBMITTER: Ahmad Zyoud  

PROVIDER: MODEL2003190002 | BioModels | 2020-03-20

REPOSITORIES: BioModels

Dataset's files

Source:
Action DRS
MODEL2003190002?filename=Loccisano2011.cps Other
MODEL2003190002?filename=Loccisano2011.xml Xml
Items per page:
1 - 2 of 2
altmetric image

Publications

Evaluation and prediction of pharmacokinetics of PFOA and PFOS in the monkey and human using a PBPK model.

Loccisano Anne E AE   Campbell Jerry L JL   Andersen Melvin E ME   Clewell Harvey J HJ  

Regulatory toxicology and pharmacology : RTP 20110201 1


Perfluoroalkyl acid carboxylates and sulfonates (PFAAs) have many consumer and industrial applications. The persistence and widespread distribution of these compounds in humans have brought them under intense scrutiny. Limited pharmacokinetic data is available in humans; however, human data exists for two communities with drinking water contaminated by PFAAs. Also, there is toxicological and pharmacokinetic data for monkeys, which can be quite useful for cross-species extrapolation to humans. Th  ...[more]

Similar Datasets

2002-01-01 | S-EPMC122062 | BioStudies
2003-01-01 | S-EPMC194216 | BioStudies
2018-01-01 | S-EPMC6533104 | BioStudies
2019-01-01 | S-EPMC6505388 | BioStudies
1000-01-01 | S-EPMC4613950 | BioStudies
2013-01-01 | S-EPMC3502013 | BioStudies
2017-01-01 | S-EPMC5839179 | BioStudies
1000-01-01 | S-EPMC4243854 | BioStudies
2016-01-01 | S-EPMC4752336 | BioStudies
2017-01-01 | S-EPMC5376394 | BioStudies