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Poudel2020 - Glucose Model


ABSTRACT: Staphylococcus aureus TCH1516 constrained COBRA model showing growth in RPMI + 10% LB.

SUBMITTER: Saugat Poudel  

PROVIDER: MODEL2005290002 | BioModels | 2024-11-26

REPOSITORIES: BioModels

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Publications

Revealing 29 sets of independently modulated genes in <i>Staphylococcus aureus</i>, their regulators, and role in key physiological response.

Poudel Saugat S   Tsunemoto Hannah H   Seif Yara Y   Sastry Anand V AV   Szubin Richard R   Xu Sibei S   Machado Henrique H   Olson Connor A CA   Anand Amitesh A   Pogliano Joe J   Nizet Victor V   Palsson Bernhard O BO  

Proceedings of the National Academy of Sciences of the United States of America 20200702 29


The ability of <i>Staphylococcus aureus</i> to infect many different tissue sites is enabled, in part, by its transcriptional regulatory network (TRN) that coordinates its gene expression to respond to different environments. We elucidated the organization and activity of this TRN by applying independent component analysis to a compendium of 108 RNA-sequencing expression profiles from two <i>S. aureus</i> clinical strains (TCH1516 and LAC). ICA decomposed the <i>S. aureus</i> transcriptome into  ...[more]

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