Kolbe2019 - Spatio-temporal liver zonation

ABSTRACT: Metabolism of the adult liver in mice and human is spatially zonated with hepatocytes along the axis from each portal vein to the nearest central vein expressing enzymes in a zonated manner. Upstream of that functional zonation, interactions of Wnt and Hh signaling are orchestrating and self-organizing the spatial expression patterns. This spatio-temporal model is derived from experimental data and explores the interacting signaling pathways. To run this model, use the free, open-source software Morpheus (download for Windows, macOS, Linux from https://morpheus.gitlab.io).

SUBMITTER: Lutz Brusch  

PROVIDER: MODEL2009110001 | BioModels | 2021-09-30

REPOSITORIES: BioModels