Project description:The kinetic model of E. coli central carbon metabolism developed by Millard et al. 2016 was extended to include the production Glycerol, Malonyl-CoA, and Beta-Alanine. This model was then used as a base to insert three independent heterologous pathways for 3-hydroxypropionate and acrylic acid production.

2021-03-09 | MODEL2010160002 | BioModels

Oliveira2020 - Glycerol pathway for Acrylic Acid production from glucose

Project description:Glycerol pathway for Acrylic Acid production from glucose.

2020-10-19 | MODEL2010040003 | BioModels

Oliveira2020 - Beta-Alanine pathway for Acrylic Acid production from glycerol

Project description:Beta-Alanine pathway for Acrylic Acid production from glycerol.

2020-10-19 | MODEL2010040002 | BioModels

Increased cardiac fatty acid oxidation in a mouse model with decreased malonyl-CoA sensitivity of CPT1B

Project description:Mitochondrial fatty acid oxidation (FAO) is an important energy provider for cardiac work and changes in cardiac substrate preference are associated with different heart diseases. Carnitine palmitoyltransferase 1B (CPT1B) is thought to perform the rate limiting enzyme step in FAO and is inhibited by malonyl-CoA. The role of CPT1B in cardiac metabolism has been addressed by inhibiting or decreasing CPT1B protein or after modulation of tissue malonyl-CoA metabolism. We assessed the role of CPT1B malonyl-CoA sensitivity in cardiac metabolism.

2021-04-26 | GSE173256 | GEO

Oliveira2020 - Extended E. coli Central Carbon Metabolism from Glucose

2020-10-07 | MODEL2010030001 | BioModels

Oliveira2020 - Malonyl-CoA pathway for 3-hydroxypropionate production from glucose

Project description:Malonyl-CoA pathway for 3-hydroxypropionate production from glucose.

2020-10-19 | MODEL2010030006 | BioModels

Oliveira2020 - Beta-Alanine pathway for Acrylic Acid production from glucose

Project description:Beta-Alanine pathway for Acrylic Acid production from glucose.

2020-10-19 | MODEL2010040001 | BioModels