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Bouchnita2020 - Model for blood coagulation under venous flow condition

ABSTRACT: A numerical simulation model to reproduce in vitro experiments of blood coagulation in microfluidic capillaries. A reduced one-equation model of thrombin distribution from the previous model under simplifying hypotheses and used to determine the conditions of clotting initiation on the platelet count, the shear rate, and the plasma composition.

SUBMITTER: Krishna Kumar Tiwari

PROVIDER: MODEL2011030003 | BioModels | 2023-04-25

REPOSITORIES: BioModels

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A mathematical model to quantify the effects of platelet count, shear rate, and injury size on the initiation of blood coagulation under venous flow conditions.

Bouchnita Anass A Terekhov Kirill K Nony Patrice P Vassilevski Yuri Y Volpert Vitaly V

PloS one 20200729 7

Platelets upregulate the generation of thrombin and reinforce the fibrin clot which increases the incidence risk of venous thromboembolism (VTE). However, the role of platelets in the pathogenesis of venous cardiovascular diseases remains hard to quantify. An experimentally validated model of thrombin generation dynamics is formulated. The model predicts that a high platelet count increases the peak value of generated thrombin as well as the endogenous thrombin potential (ETP) as reported in exp ...[more]

PMID: 32726315

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