DeBack2013 - Pancreas differentiation patterning in spatio-temporal multicellular model

ABSTRACT: This model reproduces a solution (at a=1, b=20.8, eta=1e-4) of the parameter scan in Fig. 4b of the referenced paper. Equations and other parameter values are as published. Notch signaling in competition with lateral stabilization, both mediated by cell–cell interactions, can control the cell fate decision of multi-potent pancreatic progenitor cells between the exocrine and endocrine lineages and yield a scattered spatial distribution of endocrine cells, major constituents of the later islets of Langerhans. The model file is in MorpheusML format and can be opened in the free, open-source multicellular modeling software Morpheus (download from https://morpheus.gitlab.io) to simulate the time course (movie) of lineage specification in 10.000 coupled cells in the early pancreatic tissue.

SUBMITTER: Peter Brusch  

PROVIDER: MODEL2011260001 | BioModels | 2021-10-06

REPOSITORIES: BioModels