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Sen2021 - HTimmR - A generic human CD4+ T-cell model

ABSTRACT: A generic genome-scale metabolic model (GEMs) of human CD4+ T-cells. Several cell-specific GEMs for CD4+ T-cell subsets such as Th1, Th2, Th17 and iTreg cells derived from "HTimmR" are included as additional files. The model formats are compatible with RAVEN v.2.0 toolbox.

SUBMITTER: Partho Sen

PROVIDER: MODEL2101270002 | BioModels | 2023-03-29

REPOSITORIES: BioModels

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Quantitative genome-scale metabolic modeling of human CD4<sup>+</sup> T cell differentiation reveals subset-specific regulation of glycosphingolipid pathways.

Sen Partho P Andrabi Syed Bilal Ahmad SBA Buchacher Tanja T Khan Mohd Moin MM Kalim Ubaid Ullah UU Lindeman Tuomas Mikael TM Alves Marina Amaral MA Hinkkanen Victoria V Kemppainen Esko E Dickens Alex M AM Rasool Omid O Hyötyläinen Tuulia T Lahesmaa Riitta R Orešič Matej M

Cell reports 20211101 6

T cell activation, proliferation, and differentiation involve metabolic reprogramming resulting from the interplay of genes, proteins, and metabolites. Here, we aim to understand the metabolic pathways involved in the activation and functional differentiation of human CD4<sup>+</sup> T cell subsets (T helper [Th]1, Th2, Th17, and induced regulatory T [iTreg] cells). Here, we combine genome-scale metabolic modeling, gene expression data, and targeted and non-targeted lipidomics experiments, toget ...[more]

PMID: 34758307

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