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Rommelfanger2011 - Gompertz model of melanoma tumor therapy with vesicular stomatitis virus


ABSTRACT: This mathematical model is described by the publication: Rommelfanger DM, Offord CP, Dev J, Bajzer Z, Vile RG, Dingli D. "Dynamics of melanoma tumor therapy with vesicular stomatitis virus: explaining the variability in outcomes using mathematical modeling". Gene Ther. 2012 May;19(5):543-9. doi: 10.1038/gt.2011.132. Curation Comment: Plots could not be reproduced as initial conditions for the simulations could not be found in the publication, nor estimated.

DISEASE(S): Melanoma

SUBMITTER: Emilia Chen  

PROVIDER: MODEL2109110003 | BioModels | 2021-09-11

REPOSITORIES: BioModels

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Publications

Dynamics of melanoma tumor therapy with vesicular stomatitis virus: explaining the variability in outcomes using mathematical modeling.

Rommelfanger D M DM   Offord C P CP   Dev J J   Bajzer Z Z   Vile R G RG   Dingli D D  

Gene therapy 20110915 5


Tumor selective, replication competent viruses are being tested for cancer gene therapy. This approach introduces a new therapeutic paradigm due to potential replication of the therapeutic agent and induction of a tumor-specific immune response. However, the experimental outcomes are quite variable, even when studies utilize highly inbred strains of mice and the same cell line and virus. Recognizing that virotherapy is an exercise in population dynamics, we utilize mathematical modeling to under  ...[more]

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