Ontology highlight
ABSTRACT:
DISEASE(S): Melanoma
SUBMITTER: Emilia Chen
PROVIDER: MODEL2109110004 | BioModels | 2021-09-11
REPOSITORIES: BioModels
Rommelfanger D M DM Offord C P CP Dev J J Bajzer Z Z Vile R G RG Dingli D D
Gene therapy 20110915 5
Tumor selective, replication competent viruses are being tested for cancer gene therapy. This approach introduces a new therapeutic paradigm due to potential replication of the therapeutic agent and induction of a tumor-specific immune response. However, the experimental outcomes are quite variable, even when studies utilize highly inbred strains of mice and the same cell line and virus. Recognizing that virotherapy is an exercise in population dynamics, we utilize mathematical modeling to under ...[more]