Chaudhury2020 - First order expansion model of CAR-T cell and tumour kinetics

ABSTRACT: This ordinary differential equation model of the cellular kinetics and pharmacodynamics of CAR-T cell therapy is described in the publication: Chaudhury, A., Zhu, X., Chu, L., Goliaei, A., June, C., Kearns, J. and Stein, A., 2020. Chimeric Antigen Receptor T Cell Therapies: A Review of Cellular Kinetic‐Pharmacodynamic Modeling Approaches. The Journal of Clinical Pharmacology, 60(S1). DOI: 10.1002/jcph.1691 Comment: This model is based on equations S1-S3 from the manuscript's supplemental information. A version of the approximated model, based on equations S4-S6, has been encoded separately. Curation Comment: There is a simulation error that has been attempted to be troubleshooted, however curation would be worth attempting again.

DISEASE(S): Leukemia,Lymphoma

SUBMITTER: Emilia Chen  

PROVIDER: MODEL2109110005 | BioModels | 2021-09-11

REPOSITORIES: BioModels