Hesse2021 - Interplay between core-clock and cancer drug irinotecan pharmacokinetics and -dynamics

ABSTRACT: Refined quantitative core-clock model based on the model by Relógio et al. 2011. The translation-transcription network is extended by a set of irinotecan-relevant genes, which allows to connect the core clock to the irinotecan pharmacokinetics and -dynamics model by Ballesta et al. 2011. The original model by Ballesta et al. 2011 is extended by an explicit simulation of the number of living and dead cells.

SUBMITTER: Janina Hesse  

PROVIDER: MODEL2109140001 | BioModels | 2021-09-15

REPOSITORIES: BioModels