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Lopez2022 - Genome-scale metabolic network of Haemophilus influenzae RdKW20 (iNL638)

ABSTRACT: Genome-scale metabolic network of Haemophilus influenzae RdKW20 (iNL638)

SUBMITTER: David San León Granado

PROVIDER: MODEL2204040002 | BioModels | 2023-11-27

REPOSITORIES: BioModels

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Interrogation of Essentiality in the Reconstructed Haemophilus influenzae Metabolic Network Identifies Lipid Metabolism Antimicrobial Targets: Preclinical Evaluation of a FabH β-Ketoacyl-ACP Synthase Inhibitor.

López-López Nahikari N León David San DS de Castro Sonia S Díez-Martínez Roberto R Iglesias-Bexiga Manuel M Camarasa María José MJ Menéndez Margarita M Nogales Juan J Garmendia Junkal J

mSystems 20220316 2

Expediting drug discovery to fight antibacterial resistance requires holistic approaches at system levels. In this study, we focused on the human-adapted pathogen Haemophilus influenzae, and by constructing a high-quality genome-scale metabolic model, we rationally identified new metabolic drug targets in this organism. Contextualization of available gene essentiality data within <i>in silico</i> predictions identified most genes involved in lipid metabolism as promising targets. We focused on t ...[more]

PMID: 35293791

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