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Dataset Information

WijayaTrairatphisan2021 - Logic-ODE model of stress signaling in DILI

ABSTRACT: We established a comprehensive temporal dynamic response profile of a large set of BAC-GFP HepG2 cell lines representing the following components of stress signaling: i) unfolded protein response (UPR) [ATF4, XBP1, BIP and CHOP]; ii) oxidative stress [NRF2, SRXN1, HMOX1]; iii) DNA damage [P53, P21, BTG2, MDM2]; and iv) NF-κB pathway [A20, ICAM1]. Using logic-based ordinary differential equation (Logic-ODE), we modelled the dynamic profiles of the different stress responses and extracted specific descriptors potentially predicting the progressive outcomes. Please see the most updated version on GitHub: https://github.com/saezlab/LogicODE_GFP_SR

SUBMITTER: Panuwat Trairatphisan  

PROVIDER: MODEL2206070001 | BioModels | 2022-08-02

REPOSITORIES: BioModels

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Dataset's files

Source:
Action DRS
MODEL2206070001?filename=Crosstalk_Identification_OmnipathR.R Other
MODEL2206070001?filename=DataProcessing_SR_dataset_AllSR_Full_withSD_NoCellCountNorm_v5.R Other
MODEL2206070001?filename=FitParamsAnalysis_LogicODE_GFP.R Other
MODEL2206070001?filename=SR_Network_Driver_multiCellNOpt_AllSR_PlusIFR_Parallel.R Other
MODEL2206070001?filename=SR_Network_Driver_multiCellNOpt_AllSR_PlusIFR_PostFitAnalysis.R Other
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