Dataset Information
Trares2022 - Non-canonical NF-kB pathway, Petri net
Ontology highlight
ABSTRACT:
SUBMITTER: 
Ann-Kathrin Otto
PROVIDER: MODEL2207210002 | BioModels | 2022-07-22
REPOSITORIES: BioModels
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| MODEL2207210002?filename=Trares2022%20-%20Non-canonical%20NF-kB%20pathway%20-%20Petri%20net.xml | Xml |
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Publications
The canonical and non-canonical NF-κB pathways and their crosstalk: A comparative study based on Petri nets.
Bio Systems 20211022
NF-κB is a protein complex that occurs in almost all animal cell types. It regulates the cellular immune responses to stimuli in the nucleus. Dysregulation of NF-κB can cause severe diseases like chronic inflammation, autoimmune diseases or cancer. We modeled the two major pathways leading from the external cellular stimulation of the CD40 receptor to the nuclear translocation of NF-κB dimers, the canonical and non-canonical pathway. Based on literature data, we developed two Petri net models de ...[more]
