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Dual G protein Model

ABSTRACT: A model of G protein activation using ordinary differential equations. Used to explore how the presence of two G proteins each with different properties can alter signalling output.

SUBMITTER: Theo Redfern-Nichols

PROVIDER: MODEL2306210001 | BioModels | 2025-05-22

REPOSITORIES: BioModels

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Publications

Loss-of-function Gαs rare disease variants exert mutation-specific effects on GPCR signaling.

Redfern-Nichols Theo T O'Brien Shannon L SL Huang Xianglin X Medel-Lacruz Brian B Calebiro Davide D Selent Jana J Ladds Graham G Marti-Solano Maria M

Science signaling 20250520 887

G protein-coupled receptors (GPCRs) are transmembrane detectors of extracellular signals that activate heterotrimeric G proteins to regulate intracellular responses. Because there are only 16 Gα proteins that can couple to GPCRs, variation in a single Gα can affect the function of numerous receptors. Here, we investigated two mutant forms of Gαs (L388R and E392K) that are associated with pseudohypoparathyroidism type Ic (PHPIc), a maternally inherited rare disease. Gαs is e ...[more]

PMID: 40392940

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