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GPCR Cubic Ternary Complex with G protein Cycle, Redfern-Nichols 2023

ABSTRACT: A model of G protein activation using ordinary differential equations. Used to fit to experimental data obtained from the TRUPATH platform.

SUBMITTER: Theo Redfern-Nichols  

PROVIDER: MODEL2306220001 | BioModels | 2025-05-22

REPOSITORIES: BioModels

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Publications

Loss-of-function Gα<sub>s</sub> rare disease variants exert mutation-specific effects on GPCR signaling.

Redfern-Nichols Theo T   O'Brien Shannon L SL   Huang Xianglin X   Medel-Lacruz Brian B   Calebiro Davide D   Selent Jana J   Ladds Graham G   Marti-Solano Maria M  

Science signaling 20250520 887

G protein-coupled receptors (GPCRs) are transmembrane detectors of extracellular signals that activate heterotrimeric G proteins to regulate intracellular responses. Because there are only 16 Gα proteins that can couple to GPCRs, variation in a single Gα can affect the function of numerous receptors. Here, we investigated two mutant forms of Gα<sub>s</sub> (L388R and E392K) that are associated with pseudohypoparathyroidism type Ic (PHPIc), a maternally inherited rare disease. Gα<sub>s</sub> is e  ...[more]

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