Dataset Information
Zerrouk2023 - Large scale computational modeling of the M1 synovial macrophage in rheumatoid arthritis
Ontology highlight
ABSTRACT:
SUBMITTER: 
naouel zerrouk
PROVIDER: MODEL2307180001 | BioModels | 2024-01-26
REPOSITORIES: BioModels
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| MODEL2307180001?filename=RA_M1_macrophage.xml | Xml |
Items per page: 1 - 1 of 1 |
Publications
Large-scale computational modelling of the M1 and M2 synovial macrophages in rheumatoid arthritis.
NPJ systems biology and applications 20240126 1
Macrophages play an essential role in rheumatoid arthritis. Depending on their phenotype (M1 or M2), they can play a role in the initiation or resolution of inflammation. The M1/M2 ratio in rheumatoid arthritis is higher than in healthy controls. Despite this, no treatment targeting specifically macrophages is currently used in clinics. Thus, devising strategies to selectively deplete proinflammatory macrophages and promote anti-inflammatory macrophages could be a promising therapeutic approach. ...[more]
