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Mechanotransduction & Inflammation

ABSTRACT: Deep review of our previous model MODEL2302150001 and publication Dent et al., 2015 (Mechanotransduction map: simulation model, molecular pathway, gene set) with more mechanical stimuli and specific attention to the impact on inflammation and on the AhR receptor.

SUBMITTER: Christine Nardini

PROVIDER: MODEL2406110001 | BioModels | 2025-04-03

REPOSITORIES: BioModels

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Publications

Mechanosignalling in cartilage: an emerging target for the treatment of osteoarthritis.

Hodgkinson Tom T Kelly Domhnall C DC Curtin Caroline M CM O'Brien Fergal J FJ

Nature reviews. Rheumatology 20211221 2

Mechanical stimuli have fundamental roles in articular cartilage during health and disease. Chondrocytes respond to the physical properties of the cartilage extracellular matrix (ECM) and the mechanical forces exerted on them during joint loading. In osteoarthritis (OA), catabolic processes degrade the functional ECM and the composition and viscoelastic properties of the ECM produced by chondrocytes are altered. The abnormal loading environment created by these alterations propagates cell dysfun ...[more]

PMID: 34934171

Publication: 1/38

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