Kumbale 2024 - Dioxin impact on Hepatic Cholesterol Biosynthesis
Ontology highlight
ABSTRACT:
SUBMITTER: 
Carla Kumbale
PROVIDER: MODEL2409160001 | BioModels | 2025-02-12
REPOSITORIES: BioModels
Dataset's files
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| MODEL2409160001?filename=Mevalonate_Model.m | Other |
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Publications
Hepatic cholesterol biosynthesis and dioxin-induced dysregulation: A multiscale computational approach.
Kumbale Carla M CM Zhang Qiang Q Voit Eberhard O EO
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20231010
Humans are constantly exposed to lipophilic persistent organic pollutants (POPs) that accumulate in fatty foods. Among the numerous POPs, dioxins, in particular 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), can impact several organ systems. While the hazard is clearly recognized, it is still difficult to develop a comprehensive understanding of the overall health impacts of dioxins. As chemical toxicity testing is steadily adopting new approach methodologies (NAMs), it becomes imperative to develo ...[more]
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