Abbiati2021_Avadomide-induced neutropenia model

ABSTRACT: This is the model for avadomide-induced neutropenia published by Abbiati et al. in 2021: Citation: Roberto A. Abbiati, Michael Pourdehnad, Soraya Carrancio, Daniel W. Pierce, Shailaja Kasibhatla, Mark McConnell, Matthew W. B. Trotter, Remco Loos, Cristina C. Santini & Alexander V. Ratushny. Quantitative Systems Pharmacology Modeling of Avadomide-Induced Neutropenia Enables Virtual Clinical Dose and Schedule Finding Studies. AAPS J 23, 103 (2021). https://doi.org/10.1208/s12248-021-00623-8 The model reported here is equivalent to the one provided in the original publication as Supplementary Material. The script provided contains the model equations, the initial conditions of the integration variables, and a representative set of the model parameters. It also include the instructions to execute the model in R assuming an input avadomide pharmacokinetic profile (provided as a separated csv file).

SUBMITTER: Abbiati Roberto Andrea  

PROVIDER: MODEL2412270001 | BioModels | 2025-04-07

REPOSITORIES: BioModels