Pin2025_Intestinal Organoids Model

ABSTRACT: We have developed a human small intestinal organoid (hSIO)-based mathematical modelling approach for the early prediction of GI toxicity of oral antiproliferative cancer treatments. Our mathematical model comprises hSIOs proliferative cells that become non-proliferative and eventually undergo cell death. Negative feedback loops regulate the rate of transition between these states, enhancing proliferation during the organoid expansion phase and balancing cell death in the stationary phase. Furthermore, the stationary phase is eventually followed by organoid decay, if organoids are not split and medium refreshment is not performed, which we modelled by accounting for the toxic effect of accumulated cell-produced waste material. Regarding drug-induced toxicity, the model implements cycle arrest and cell death of proliferative cells associated with exposure of oncology drugs

SUBMITTER: Carmen Pin  

PROVIDER: MODEL2509110001 | BioModels | 2026-05-01

REPOSITORIES: BioModels