Heat shock response network model from Guilbert et al. 2020

ABSTRACT: The model describes the mammalian heat shock response network using four dynamical variables: temperature, misfolded proteins (MFP), HSP mRNA, and heat shock proteins (HSP). Heat stress increases protein denaturation, generating MFPs that compete with HSF1 for binding to HSP chaperones. This sequestration mechanism releases HSF1, which activates HSP transcription and thereby generates a negative feedback restoring proteostasis. The model also includes HSP-dependent translation and provides an analytical estimate of HSF1 activation, (F_{\mathrm{Th}}), corresponding to the fraction of HSF1 associated with nuclear stress bodies.

SUBMITTER: Quentin Thommen  

PROVIDER: MODEL2608180003 | BioModels | 2026-09-02

REPOSITORIES: BioModels