Minimal dynamical thermal dose model - Ladjimi et al. 2019

ABSTRACT: The model provides a minimal mechanistic description of cellular survival under hyperthermia. Heat induces the production of misfolded proteins, which are either degraded or repaired by molecular chaperones. The repair process is saturable because chaperone resources are limited, causing misfolded proteins to accumulate when the thermal stress exceeds the cellular repair capacity. Cell survival decreases according to the accumulated misfolded-protein burden. This nonlinear repair limitation allows the model to reproduce thermal dose time-profile effects that cannot be captured by the conventional CEM43 description, including the different survival responses produced by fast-rise/slow-decay and slow-rise/fast-decay temperature profiles.

SUBMITTER: Quentin Thommen  

PROVIDER: MODEL2608180004 | BioModels | 2026-09-02

REPOSITORIES: BioModels