ABSTRACT:
This model is based closely on the one from Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. This is a stripped down version with only the essential components of the feedback loop:PKC, Ras and the MAPK cascade, and PLA2 in the synapse. The upregulation of MKP-1 is not incorporated in this model since it is treated as a fixed regulatory input. This model was used to develop figures 2 - 4 which show the bistable region of parameter space when the regulatory inputs Ca, PP2A and MKP-1 are varied. This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.
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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.