Ontology highlight
ABSTRACT:
SUBMITTER: Sharat Vayttaden
PROVIDER: MODEL9079179924 | BioModels | 2005-01-01
REPOSITORIES: BioModels
Bhalla Upinder S US Ram Prahlad T PT Iyengar Ravi R
Science (New York, N.Y.) 20020801 5583
Intracellular signaling networks receive and process information to control cellular machines. The mitogen-activated protein kinase (MAPK) 1,2/protein kinase C (PKC) system is one such network that regulates many cellular machines, including the cell cycle machinery and autocrine/paracrine factor synthesizing machinery. We used a combination of computational analysis and experiments in mouse NIH-3T3 fibroblasts to understand the design principles of this controller network. We find that the grow ...[more]