Transcription profiling of humans and chimpanzees in brain, heart, liver, kidney, and testis

ABSTRACT: The determination of the chimpanzee genome sequence provides a means to study both structural and functional aspects of the evolution of the human genome. Here we compare humans and chimpanzees with respect to differences in expression levels and protein-coding sequences for genes active in brain, heart, liver, kidney, and testis. We find that the patterns of differences in gene expression and gene sequences are markedly similar. In particular, there is a gradation of selective constraints among the tissues so that the brain shows the least differences between the species whereas liver shows the most. Furthermore, expression levels as well as amino acid sequences of genes active in more tissues have diverged less between the species than have genes active in fewer tissues. In general, thes

ORGANISM(S): Pan troglodytes

SUBMITTER: Philipp Khaitovich 

PROVIDER: E-AFMX-11 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress