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Transcription profiling by array of Mycobacterium tuberculosis to analyse the regulatory role of the HigA antitoxin

ABSTRACT: Data is also available from BuG@Sbase

ORGANISM(S): Mycobacterium tuberculosis

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PROVIDER: E-BUGS-107 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Analyzing the regulatory role of the HigA antitoxin within Mycobacterium tuberculosis.

Fivian-Hughes Amanda S AS Davis Elaine O EO

Journal of bacteriology 20100628 17

Bacterial chromosomally encoded type II toxin-antitoxin (TA) loci may be involved in survival upon exposure to stress and have been linked to persistence and dormancy. Therefore, understanding the role of the numerous predicted TA loci within the human pathogen Mycobacterium tuberculosis has become a topic of great interest. Antitoxin proteins are known to autoregulate TA expression under normal growth conditions, but it is unknown whether they have a more global role in transcriptional regulati ...[more]

PMID: 20585061

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