Comparative genomic hybridization of 94 Yersinia enterocolitica strains to identify genetic differences related to pathogenicity

ABSTRACT: Yersinia enterocolitica, an important cause of human gastroenteritis generally caused by the consumption of livestock, has traditionally been categorized into three groups with respect to pathogenicity, i.e., nonpathogenic (biotype 1A), low pathogenicity (biotypes 2 to 5), and highly pathogenic (biotype 1B). However, genetic differences that explain variation in pathogenesis and whether different biotypes are associated with specific nonhuman hosts are largely unknown. In this study, we applied comparative phylogenomics (whole-genome comparisons of microbes with DNA microarrays combined with Bayesian phylogenies)to investigate a diverse collection of 94 strains of Y.enterocolitica consisting of 35 human, 35 pig, 15 sheep, and 9 cattle isolates from nonpathogenic, low-pathogenicity, and hi

INSTRUMENT(S): Lightwave

ORGANISM(S): Yersinia enterocolitica

SUBMITTER:  

PROVIDER: E-BUGS-36 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress