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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of Mycobacterium tuberculosis infected human dendritic cells and macrophages and M. tuberculosis grown aerobically to investigate host-pathogen cross-talk

ABSTRACT: Data is also available from http://bugs.sgul.ac.uk/E-BUGS-58

INSTRUMENT(S): Variable Atmosphere Incubator, Bioanalyser

ORGANISM(S): Mycobacterium tuberculosis

SUBMITTER:

PROVIDER: E-BUGS-58 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Probing host pathogen cross-talk by transcriptional profiling of both Mycobacterium tuberculosis and infected human dendritic cells and macrophages.

Tailleux Ludovic L Waddell Simon J SJ Pelizzola Mattia M Mortellaro Alessandra A Withers Michael M Tanne Antoine A Castagnoli Paola Ricciardi PR Gicquel Brigitte B Stoker Neil G NG Butcher Philip D PD Foti Maria M Neyrolles Olivier O

PloS one 20080102 1

<h4>Background</h4>Transcriptional profiling using microarrays provides a unique opportunity to decipher host pathogen cross-talk on the global level. Here, for the first time, we have been able to investigate gene expression changes in both Mycobacterium tuberculosis, a major human pathogen, and its human host cells, macrophages and dendritic cells.<h4>Methodology/principal findings</h4>In addition to common responses, we could identify eukaryotic and microbial transcriptional signatures that a ...[more]

PMID: 18167562

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