Comparative genomic hybridization of Beijing and non-Beijing Myocobacterium tuberculosis isolates from Myanmar

ABSTRACT: Background. The Beijing family of Mycobacterium tuberculosis is dominant in countries in East Asia. Genomic polymorphisms are a source of diversity within the M.tuberculosis genome and may account for the variation of virulence among M.tuberculosis isolates. To date there are no studies that have examined the genomic composition of M.tuberculosis isolates from the high TB-burden country, Myanmar. Methodology/Principle findings. Twenty-two M.tuberculosis isolates from Myanmar were screened on whole-genome arrays containing genes from M.tuberculosis H37Rv, M.tuberculosis CDC1551 and M.bovis AF22197. Screening identified 198 deletions or extra regions in the clinical isolates compared to H37Rv. Twenty-two regions differentiated between Beijing and non-Beijing isolates and were verified by PC

ORGANISM(S): Mycobacterium tuberculosis

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PROVIDER: E-BUGS-66 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress