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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of Staphylococcus aureus following inhibition of early-stage cell-wall biosynthesis

ABSTRACT: Data is also available from http://bugs.sgul.ac.uk/E-BUGS-71

INSTRUMENT(S): Bioanalyser

ORGANISM(S): Staphylococcus aureus

SUBMITTER:

PROVIDER: E-BUGS-71 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcriptional signature following inhibition of early-stage cell wall biosynthesis in Staphylococcus aureus.

O'Neill A J AJ Lindsay J A JA Gould K K Hinds J J Chopra I I

Antimicrobial agents and chemotherapy 20090121 4

To facilitate mode of action studies on antibacterial inhibitors of early-stage cell wall biosynthesis (CWB), we determined the transcriptional response of Staphylococcus aureus to depletion/inhibition of enzymes in this pathway by DNA microarray analysis. We identified a transcriptional signature distinct from that previously observed following exposure to inhibitors of late-stage CWB. ...[more]

PMID: 19164146

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