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Transcription profiling of S. aureus (MRSA) clones with the same USA300 PFGE profile

ABSTRACT: Data is also available from http://bugs.sgul.ac.uk/E-BUGS-77

ORGANISM(S): Staphylococcus aureus

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PROVIDER: E-BUGS-77 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Two distinct clones of methicillin-resistant Staphylococcus aureus (MRSA) with the same USA300 pulsed-field gel electrophoresis profile: a potential pitfall for identification of USA300 community-associated MRSA.

Larsen Anders Rhod AR Goering Richard R Stegger Marc M Lindsay Jodi A JA Gould Katherine A KA Hinds Jason J Sørum Marit M Westh Henrik H Boye Kit K Skov Robert R

Journal of clinical microbiology 20090916 11

Analysis of methicillin-resistant Staphylococcus aureus (MRSA) characterized as USA300 by pulsed-field gel electrophoresis identified two distinct clones. One was similar to community-associated USA300 MRSA (ST8-IVa, t008, and Panton-Valentine leukocidin positive). The second (ST8-IVa, t024, and PVL negative) had different molecular characteristics and epidemiology, suggesting independent evolution. We recommend spa typing and/or PCR to discriminate between the two clones. ...[more]

PMID: 19759225

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