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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of Mycobacterium tuberculosis treated with benzothiazinones which kill M. tuberculosis by blocking arabinan synthesis

ABSTRACT: Data is also available from BuG@Sbase

INSTRUMENT(S): Nanodrop N1000 spectrophotometer

ORGANISM(S): Mycobacterium tuberculosis

SUBMITTER:

PROVIDER: E-BUGS-80 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis.

Makarov Vadim V Manina Giulia G Mikusova Katarina K Möllmann Ute U Ryabova Olga O Saint-Joanis Brigitte B Dhar Neeraj N Pasca Maria Rosalia MR Buroni Silvia S Lucarelli Anna Paola AP Milano Anna A De Rossi Edda E Belanova Martina M Bobovska Adela A Dianiskova Petronela P Kordulakova Jana J Sala Claudia C Fullam Elizabeth E Schneider Patricia P McKinney John D JD Brodin Priscille P Christophe Thierry T Waddell Simon S Butcher Philip P Albrethsen Jakob J Rosenkrands Ida I Brosch Roland R Nandi Vrinda V Bharath Sowmya S Gaonkar Sheshagiri S Shandil Radha K RK Balasubramanian Venkataraman V Balganesh Tanjore T Tyagi Sandeep S Grosset Jacques J Riccardi Giovanna G Cole Stewart T ST

Science (New York, N.Y.) 20090319 5928

New drugs are required to counter the tuberculosis (TB) pandemic. Here, we describe the synthesis and characterization of 1,3-benzothiazin-4-ones (BTZs), a new class of antimycobacterial agents that kill Mycobacterium tuberculosis in vitro, ex vivo, and in mouse models of TB. Using genetics and biochemistry, we identified the enzyme decaprenylphosphoryl-beta-d-ribose 2'-epimerase as a major BTZ target. Inhibition of this enzymatic activity abolishes the formation of decaprenylphosphoryl arabinos ...[more]

PMID: 19299584

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Project description:Data is also available from <ahref=http://bugs.sgul.ac.uk/E-BUGS-81 target=_blank>BuG@Sbase</a>

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