Transcription profiling of Mycobacterium bovis to determine genetic requirements for fast and slow growth in Mycobacteria

ABSTRACT: Mycobacterium tuberculosis infects a third of the world's population. Primary tuberculosis involving active fast bacterial replication is often followed by asymptomatic latent tuberculosis, which is characterised by slow or non-replicating bacteria. Reactivation of the latent infection involving a switch back to active bacterial replication can lead to post-primary transmissible tuberculosis. Mycobacterial mechanisms involved in slow growth or switching growth rate provide rational targets for the development of new drugs against persistent mycobacterial infection. Using chemostat culture to control growth rate we screened a transposon mutant library by Transposon site hybridization (TraSH) selection to define the genetic requirements for slow and fast growth of Mycobacterium bovis (BCG) a

ORGANISM(S): Mycobacterium bovis

SUBMITTER:  

PROVIDER: E-BUGS-83 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress