Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of pig endothelial cells from animials fed high or low cholesterol diet shows brief hypercholesterolemia induces side-specific protective changes in pig aortic valve endothelia

ABSTRACT: The study demonstrates (i) spatial heterogeneity of endothelial responses to hypercholesterolemia in the aortic valve, (ii) that endothelial metabolism is not dysfunctional in early focal lipid insudation, and (iii) that protective endothelial pathways induced by hypercholesterolemia may initially inhibit the onset of AVS in regions most susceptible.

ORGANISM(S): Sus scrofa

SUBMITTER: Peter Davies

PROVIDER: E-CBIL-47 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Hypercholesterolemia induces side-specific phenotypic changes and peroxisome proliferator-activated receptor-gamma pathway activation in swine aortic valve endothelium.

Guerraty Marie A MA Grant Gregory R GR Karanian John W JW Chiesa Oscar A OA Pritchard William F WF Davies Peter F PF

Arteriosclerosis, thrombosis, and vascular biology 20091119 2

<h4>Unlabelled</h4>Background- The endothelium of healthy aortic valves expresses different phenotypes on the aortic and ventricular sides. On the aortic side, which is susceptible to aortic valve sclerosis, there is a balanced coexpression of both propathological and protective pathways. Side-specific global gene expression can address endothelial phenotype balance in early aortic valve sclerosis.<h4>Methods and results</h4>Adult male swine were fed a hypercholesterolemic or an isocaloric norma ...[more]

PMID: 19926833

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Dataset Information

Transcription profiling of pig endothelial cells from animials fed high or low cholesterol diet shows brief hypercholesterolemia induces side-specific protective changes in pig aortic valve endothelia

Publications

Hypercholesterolemia induces side-specific phenotypic changes and peroxisome proliferator-activated receptor-gamma pathway activation in swine aortic valve endothelium.

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