Transcription profiling of Drosophila samples of wild type, aly, can, zaa and zab testes

ABSTRACT: Drosophila melanogaster males mutant for any meiotic arrest gene have defective spermatogenesis, with cells arresting as primary spermatocytes, and failing to progress to later stages. This phenotype is remarkably similar to meiosis I maturation arrest azoospemia in humans. Drosophila meiotic arrest genes can be categorised as "aly-class" or "can-class". The aly-class (aly, zaa and zab) regulates both meiotic division and male germ line differentiation by controlling transcriptional activation of a large set of target genes in primary spermatocytes. This set includes genes required for cell cycle progression and those required for spermatid differentiation. The can-class control transcription of the same set of differentiation genes, but not cell cycle genes. aly belongs to a protein famil

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Debashis Rana 

PROVIDER: E-FLYC-5 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress