Transcription profiling by array of human 16 cell lines to investigate correlated and anticorrelated expression

ABSTRACT: We performed a global analysis of both miRNAs and mRNAs expression across sixteen human cell lines and extracted negatively correlated pairs of miRNA and mRNA which indicate miRNA-target relationship. The many of known-target of miR-124a showed negative correlation, suggesting our analysis were valid. We further extracted physically relevant miRNA-target gene pairs, applying computational target prediction algorism with inverse correlations of miRNA and mRNA expression. Furthermore, Gene Ontology-based annotation and functional enrichment analysis of the extracted miRNA-target gene pairs indicated putative functions of miRNAs. Experiment Overall Design: 16 samples were analyzed. Replicate were not included.

This experiment was reloaded into ArrayExpress in November 2010 after manu

ORGANISM(S): Homo sapiens

SUBMITTER: Yoshinao Ruike 

PROVIDER: E-GEOD-10021 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress