A compendium of antibiotic-induced transcription profiles reveals broad regulation of P. multocida virulence genes

ABSTRACT: Treatment of bacteria with antibiotics at or close to the inhibitory concentration leads to specific transcriptional responses often affecting target genes and targets pathways. A dataset of transcriptional profiles (compendium) induced by antibiotics with known mode-of-action (MoA) can be used to gain information on the putative MoA of novel substances with unknown MoAs. We used a Pasteurella multocida microarray to generate a compendium of transcriptional profiles and to obtain information on the putative MoA of a novel antibiotic compound. We also show a strong impact of the bacteriostatic antibiotics on P. multocida virulence gene transcription. Keywords: antibiotica treatment, time course Midlog-grown cultures of P. multocida were treated for 10 or 30 min with 8 different antibiotics

ORGANISM(S): Pasteurella multocida

SUBMITTER: Paul Selzer 

PROVIDER: E-GEOD-10051 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress