Murine Spleen: Wild type vs Brx haploinsufficiency

ABSTRACT: Comaprison of the gene expression profiles of the spleen between wild type and Brx haploinsuffieint mice Nuclear factor of activated T-cells 5 (NFAT5) is a transcription factor that regulates hyperosmolarity-responsive genes and helps activated T lymphocytes adapt to and discharge their functions in hyperosmolar environments. We report here that the Rho-type guanine nucleotide exchange factor (GEF) Brx is essential for increased NFAT5 expression in response to osmotic stress in lymphoid tissues. Indeed, brx haploinsufficient mice expressed significantly less NFAT5 in their spleens than wild type controls and their splenocytes had a defective response to osmotic stress in vitro. Haploinsufficient mice also had smaller-sized spleens containing fewer splenocytes, as well as a defective immun

ORGANISM(S): Mus musculus

SUBMITTER: Tomoshige Kino 

PROVIDER: E-GEOD-10117 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress