Gene Expression Profile of NHE1 Null Mutation
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Dan Zhou
PROVIDER: E-GEOD-1013 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Na+/H+ exchanger 1 deficiency alters gene expression in mouse brain.
Zhou Dan D Xue Jin J Gavrialov Orit O Haddad Gabriel G GG
Physiological genomics 20040811 3
Na(+)/H(+) exchanger 1 (NHE1) is well known to function as a major regulator of intracellular pH (pH(i)). It is activated by low pH(i) and exchanges extracellular Na(+) for intracellular H(+) to maintain cellular homeostasis. Despite the fact that we now have evidence suggesting other roles for NHE1, there has been no comprehensive study investigating its role as a signaling molecule. Toward this aim, we used in this study NHE1 null mutant mice and cDNA microarrays to investigate the effects of ...[more]
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