Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma (Training Set, HCC)

ABSTRACT: Background: It is a challenge to identify those patients who, after undergoing potentially curative treatments for hepatocellular carcinoma, are at greatest risk of recurrence. Such high-risk patients could receive novel interventional measures. An obstacle to the development of genome-based predictors of outcome in patients with hepatocellular carcinoma has been the lack of a means to carry out genomewide expression profiling of fixed, as opposed to frozen, tissues. Methods: We aimed to demonstrate the feasibility of gene-expression profiling of more than 6000 human genes in formalin-fixed paraffin-embedded tissues. We applied the method to tissues from 307 patients with hepatocellular carcinoma, from four series of patients, to discover and validate a gene-expression signature associated

ORGANISM(S): Homo sapiens

SUBMITTER: Yujin Hoshida 

PROVIDER: E-GEOD-10141 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress