Transcription profiling of Escherichia coli treated with cefsulodin and mecillinam, alone at the minimum inhibitory concentration

ABSTRACT: Gram-negative bacteria possess stress responses to maintain the integrity of the cell envelope. Stress sensors monitor outer membrane permeability, envelope protein folding, and energization of the inner membrane. The systems used by Gram-negative bacteria to sense and combat stress resulting from disruption of the peptidoglycan layer are not well characterized. The peptidoglycan layer is a single molecule that completely surrounds the cell and ensures its structural integrity. During cell growth new peptidoglcyan subunits are incorporated into the peptidoglycan layer by a series of enzymes called the penicillin-binding proteins (PBPs). To explore how Gram-negative bacteria respond to peptidoglycan stress, global gene expression analysis was used to identify Escherichia coli stress re

ORGANISM(S): Escherichia coli K12

SUBMITTER: Mary Elizabeth Laubacher 

PROVIDER: E-GEOD-10159 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress